Batch Processing Solutions: Pelletization.

Using our breakthrough technology and the experience gained during many successful installations, GEA provides seamlessly integrated pellet production plant. Our history of working with integrated systems is second to none and we continue to provide the highest quality and support for each of our core technologies.

For example, the unique, modular concept of the NICA Pelletizing Plant enables us to meet your process requirements exactly, whereas mixer/granulator, extruder and spheronizer modules can be combined to create a completely integrated pellet production plant, or selected individually to suit specific requirements.

For maximum flexibility, the modules can be operated in either batch or continuous mode, and can be used as standalone products or integrated with other up- or downstream equipment (such as a fluid bed processor). Ideal for both product development and full-scale production applications, scale-up is easy; it’s simply a factor of processing time.

With the advantage of being a single source of supply, GEA can supply a single fluid bed unit, such as an MP-Classic or MP-Advanced, or a FlexStream fluid bed processor that enables granulation, drying and pellet coating in one single unit.

The Benefits of Pellets • Enhanced drug dissolution • Ease of coating and improved aesthetic appearance • Desirable release characteristics (sustained, controlled,

delayed, site-specific or pulsatile delivery) • Uniform packing • Ease of capsule filling (improved flow properties) • Even distribution in the GI tract and less irritation • Flexible formulation development and manufacture • Chemically incompatible products can be formulated into

pellets and delivered in a single dosage form.

Pharmaceutical pellets for optimized release characteristics.

Flexible, efficient and easy to formulate multiparticulate drug delivery systems.

9 Batch Processing Solutions — Granulation.