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THE GEA PHARMA SOLIDS TEST CENTERS IN BELGIUM. The Simply Better way to improve your products and optimize your processes.

The GEA Pharma Solids Test Centers represent our continued commitment to and our ongoing support for the current and future pharmaceutical industry. With a total footprint of over 1500 m2, including 200 m2 of technical space, the Test Centers epitomize the state-of-the-art in oral solid dosage (OSD) form testing, development and optimization, and offers a full range of batch and continuous manufacturing technologies. From process enhancement to real-life simulations and test and loan machines, we provide a unique range of services that are designed to improve production and enhance the quality of your product.

The Test Centers offer a wealth of opportunity for GEA’s clients, including customer demonstrations and trials, training sessions and hands-on lab experience, as

well as CQA evaluation and updates on what can be achieved with our equipment.

By delivering everything from technical know-how and process insight to project management and the service you need to meet your objectives and bring your plans to fruition, we supply the added value and the deep-rooted knowledge that counts.

Whatever the scale of your operation or application, we have the capability to make your concept a reality, enhance your process, improve your production efficiency and deliver the ongoing support to make your business a success.

Take a Simply Better approach to reaching your goals and staying ahead of the competition.

INVESTING IN THE FUTURE OF PHARMA. Test, develop and optimize your products and processes with cutting-edge batch and continuous technologies.

Committed to our Customers.

With our unparalleled history of expertise in processing OSDs, from pills and pellets to MUPS, and our tried and tested technologies, our focus is on price-performance leadership, safety and quality.

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In our Test Centers, we combine advanced in-house technology with a thorough understanding of the processing industries to help customers maximize their development results, gain more know-how and discover additional opportunities for their applications.

The Test Centers support the development of new technologies and increase the fundamental understanding of existing pharmaceutical processes and technologies.

Furthermore, we can help with new installations by providing unit-specific operator training. This on-site hands-on guidance is critical to understanding the functionality of the equipment and provides a solid foundation in terms of operation and maintaining optimum manufacturing conditions.

Additionally, we provide a unique range of services that are designed to enhance production and expedite time-to-market, such as testing new concepts (equipment/ advanced controls), developing and refining new procedures to increase both our understanding and the capabilities of our equipment.

We can help with process development of • tablets • pellets • effervescents • MUPS • inhalable fine powders • granules, dragées and crystals.

Get on the fast track to product success.

A well-established expert in the pharmaceutical processing and manufacturing industry with a long history of experience, GEA has developed a deep and thorough understanding of the challenges you face, the hurdles you need to overcome and the goals you want to achieve.

DISCOVER NEW OPPORTUNITIES.

We believe our services greatly benefit anyone involved in pharmaceutical R&D, equipment selection, process optimization and product development.

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Whatever your application, no matter how challenging, GEA’s powder handling, granulating, pelletizing, drying, compression and coating solutions will meet and exceed your individual requirements.

The Test center in Wommelgem, Antwerp, enables you to investigate all the batch- based solid dosage production techniques offered by GEA, at laboratory, pilot or production scale. Our experts are available to provide objective, unbiased advice on the merits and implications of each process and to help you to choose the best solution for your specific application. Some of the key application areas that are on offer include the following:

• IBC blending • high shear granulation (top and bottom drive) (PMA60, PMA300 and GRAL300)

• fluid bed FlexStream® granulation, drying and coating (MP2 and MP4/5)

• fluid bed top spray granulation and Flexstream coating

• containment measures (BUCK® valves, Hicoflex®).

• single-pot processing (UltimaPro25) • extrusion/spheronization (NICA IPS25) • tablet compression (MODUL P and MODUL S)

• milling/calibration (Different Quadro® mills).

From powder to coated tablet and from R&D to full-scale manufacturing.

BATCH PROCESSING CAPABILITIES.

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The quest for continuous innovation is the force that drives us every day, and flexibility, performance, accuracy and control are the criteria that focus our thinking.

Everything we do is aimed at improving these key factors to help you to make better products and improve productivity.

Below you can find of examples of the innovative solutions that can be tested :

Integrated Small-Scale Granulation and Drying At the heart of GEA’s small-scale and R&D portfolio is PharmaConnect®, which allows a number of diverse process modules to be docked to a single control unit. The Test Center in Wommelgem offers both a mobile and a permanently installed PharmaConnect® system with high shear granulation modules.

Fluid Bed Processing Using proven GEA technology to achieve fluid bed granulation, drying and pellet coating in a single module, FlexStream® is a new multipurpose system that addresses the current shortfalls of traditional fluid bed processing, including linear scale-up, fully contained loading and unloading for pharmaceutical applications. In the Test Center, this technology can be tested and demonstrated at lab, pilot and production scale.

Optimized Pellet and MUPS Formulations Pharmaceutical pellets offer many additional features compared with conventional tablets. GEA is able to offer all the typically used pelletization processes and help you to select the one that best suits your needs, including powder and liquid layering, melt and wet granulation processes, and innovative MUPS production technology that eliminates segregation and significantly increases process yields.

Batch Processing Capabilities.

Mobile PharmaConnect® with 60-L PMA bowl – available for trials onsite and for rental.

NICA IPS25 for extrusion and spheronisation – available for trials onsite and for rental.

UltimaPro Single Pot Processors offer a choice of mixing, granulation and drying options integrated into one processing vessel.

IBC blending at the GPSC.

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Increasing knowledge… …whatever your application.

Our permanent staff of experienced engineers, technicians, and industrial pharmacists can assist with any production problems, new developments and the modification of GEA technology to meet specific needs.

Whether it’s high shear granulation or inhalation blending, extrusion and spheronization or IBC blending, safety, containment, product flow and building requirements are in- built for full integration and optimum process efficiency.

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The ConsiGma® concept enables small amounts of product to be processed and developed quickly and efficiently. And, once a formulation has been optimized, it can be reliably reproduced in pilot, clinical or production batches, simply by running the machine for longer, avoiding scale-up problems and the lengthy validation processes that hinder bringing new products to market faster.

ConsiGma® is a Six Sigma-inspired manufacturing platform, incorporating different technologies to produce oral solid dosage forms in a continuous, cost-efficient way:• • by collecting more information during R&D in a short time with less product

• by excluding risky, time- and product- consuming scale-up exercises

• by introducing online measurement and closed loop control for real-time release (Six Sigma production)

• by incorporating flexible batch sizes (JIT production) and reducing inventory

• by decreasing the energy cost per tablet, reducing the environmental impact.

The Test Center in Wommelgem enables you to investigate the possibilities that continuous manufacturing can offer for your production. Following technologies are available for testing: • ConsiGma® 1 for initial continuous wet granulation trials, feasibility and first DoE tests.

• Continuous Tableting Line CTL 25: a continuous wet granulation and drying production line, able to operate at a nominal throughput of 25 kg/h. Tablet compression and tablet coating can immediately be linked to the granulation and drying process, to evaluate the full continuous process.

• Offline Compact Feeder (CF): to investigate the right set-up of the feeder for your ingredients before moving to the full production line.

• ConsiGma® CDC50 for continuous direct compression • ConsiGma® Coater Continuous Coating of tablets produced by the CTL25 or CDC50.

At GEA, we believe that continuous processing improves the quality of pharmaceutical end products by focusing on quality during the whole product lifecycle not just “tested in” quality — and by understanding the capability of your processes, managing sources of variability and decreasing any associated risks.

CONTINUOUS PROCESSING CAPABILITIES.

ConsiGma® 1 for R&D scale continuous granulation.

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Continuous Direct Compression: Available in the Test Center in Wommelgem for product trials, the ConsiGma® CDC is a complete tablet production facility with embedded quality control in one machine, integrating four key GEA technologies — accurate loss- in-weight feeding, continuous blending, GEA compression technology and the online measurement of CQAs (Critical Quality Attributes) with a Lighthouse Probe®.

Continuous Processing Capabilities.

Less input, more output. Competive Advantage.

ConsiGma® provides maximum productivity in an energy efficient way, has been tested using a wide variety of formulations and more than 100 ConsiGma® units are currently in use in pharmaceutical research and manufacturing centers worldwide

GEA combines advanced in-house technology with a thorough understanding of the process industries to help customers maximize their development results, gain more know-how and discover additional opportunities for their applications.

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The revolutionary, high performance ConsiGma® coater.

Continuous Processing Capabilities.

High Performance Tablet Coating Technology. The ConsiGma® coater is a revolutionary, high performance tablet coating technology that accurately deposits con- trolled amounts of coating materials on tablets. Designed specifically to be an integral part of the ConsiGma® contin- uous tableting lines, the ConsiGma® coater is able to pro- cess small quantities of tablets at very high rates, offering improved heat and mass transfer.

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Process Optimization.

GEA is pioneering the implementation of smaller, more flexible, continuous processing technologies that will transform the future of pharmaceutical development and manufacturing — and deliver customized quantities of drugs to patients in need in a quick and efficient way.

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COMPRESSION TECHNOLOGY CAPABILITIES.

In the Test Center in Halle, GEA holds specific expertise on compression technology. The site in Halle has a Test Center with multiple tablet presses, ready to support your research in R&D, low throughput and high throughput monolayer and bilayer tabletting.

The newest range of NexGen tablet presses is available, as well as a MUPS testing rig. The center also has capabilities for industrial tabletting applications.

* The Add Better label relates to the serial product GEA NexGen Press® 30, released in August 2022.

Step into the Era of Advanced Tablet Manufacturing.

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At our technology centers, you can test any unit operation, from lab- to pilot-scale, or perform comparative process studies with our skilled operators by testing complete process trains.

In addition, our permanent staff of experienced engineers, technicians and industrial pharmacists can assist with any production problems, new developments and the modification of GEA technology to meet specific needs.

Our personnel remain constantly up to date with the most recent developments in the industry to be able to provide you with the best assistance possible.

Committed to advancing our customers’ research and development activities, GEA’s pharmaceutical technology test centers in Belgium, Denmark, Germany, the UK, the USA, Singapore, China and South Korea provide global technical support and know-how to the pharmaceutical industry.

Plus, often in collaboration with universities and independent research facilities, GEA engages in scientific experimentation to better understand the procedures and processes involved in manufacturing.

With a long history of solid dosage form expertise, including hundreds of formulations, everyone at the test centers is committed to going the extra mile to meet customer expectations. Wherever you are in the world, whatever your application, we’ll take you further, faster.

GEA recognizes the important role that training plays in the proper use of its equipment. Whether the need is theory, general operational training or tuition on a specific process, GEA can helping you to learn to use our technology to the fullest.

To support the needs of our customer base, regular training courses are scheduled in our Test Centers. Custom classes can also be arranged, either at the customer’s own facility or in our test centers. Looking for a particular training course? Feel free to contact our Director of the Test Centers, Evelien Devroey, for assistance. Evelien.devroey@gea .com

Currently available courses include • Understanding Continuous Processing • Successful Tableting: How to Achieve Operational Excellence

• Tableting Technology Seminars (operator, maintenance and process level)

• Customized training, etc.

FROM TESTING TO TROUBLESHOOTING. Achieve operational excellence with expert guidance and instruction (from GEA).

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MEETING YOUR NEEDS. Applications Core Technologies

Granulation

Tablet Compression

Drying & Particle Processing

Product Handling

Addition of Liquid & Ingredients Continuous Blending (NEW) Continuous Granulation Dry Powder Blending Fluid Bed Granulation Fluidized Spray Drying High Shear Mixing High Shear Granulation Integrated Granulation Liquid Mixing & Blending Melt Granulation

Contained Tableting Continuous Coating Continuous Direct Compression Continuous Tableting DC & WG Industrial Compression Tablet Coating Tablet Compression

Dispensing & Dosing Dry Bonding Extrusion Fluid Bed Drying Layering Melt Pelletizing Microwave Drying Particle Pellet Coating Pelletizing Single-Pot Processing Spheronization Spray Drying Vacuum Drying Wet Pelletizing

Contained Materials Handling Containment Dispensing & Dosing Dispensing & Weighing Handling of Bulk Ingredients Mixing & Blending Tablet Handling

Expertise

Formulation Development** Product Testing & Development

Anti-Cancer Treatments* Process Optimization

Antibiotics* & Anti-Infectives Formulation**

Effervescents Customer Trials

High Volume Production Training & Education

Highly Potent APIs* Start-Up Assistance

Hormones* Application Development

Inhalable Fine Powders Price-Performance Leadership

MUPS Higher Quality

Pellets Faster Time-to-Market

Tablets Available services will depend on the location of the test center. Please enquire for details. * Acceptance of API depends on the risk analysis by the EH&S department. ** In collaboration with our partners

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The GEA Pharma Solids Test Centers in Belgium. To discover more or organize a test, demonstration or training session, contact our dedicated, passionate and experienced team.

Further information

Evelien Devroey Director of GEA Pharma Solids Center (GPSC) evelien.devroey@gea.com gea.com

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© GEA Process Engineering nv 2025. All rights reserved. Subject to modifications. BUCK®, ConsiGma®, FlexStream®, Hicoflex®, Lighthouse Probe® & PharmaConnect® are registered as trademarks in several countries worldwide.

GEA Pharma & Healthcare GEA Process Engineering nv

Keerbaan 70, B-2160, Wommelgem, Belgium Tel +32 2 350 1211

Bergensesteenweg 186, B-1500 Halle, Belgium Tel +32 2 363 8300

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