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SINGLE-POT PROCESSING. Flexible and contained production by design.

COMPACT AND COST-EFFECTIVE.

With high-shear granulation technology at its core, single-pot processing relies on the application of a vacuum within the bowl to dry the wet mass. This technique allows pharmaceutical compounds to be dried at very low temperatures and, even if organic solvents are used during the process, an efficient solvent recovery system means that environmental exhaust levels are minimal.

Single-pot processing is a very compact and flexible technology; this is achieved by incorporating several manufacturing steps into one machine. This reduces the capital cost of the equipment and, by reducing the cGMP and technical space required for granule production, the overall project cost.

The swinging bowl option enhances this flexibility even further by being able to process older formulations to a high-quality standard. Quick product changeover is simple and efficient, and the equipment is clean-in-place (CIP)-compatible.

In addition, because of its very nature, a single- pot process is contained. No transfers are required between process steps, except to load the raw materials and unload the dry granules. This not only protects the operators from potent actives, it also prevents product being exposed to external influences such as heat, light or moisture.

A range of process control systems is available that offer maximum flexibility and functionality for process visualization, automation and data recording.

And, by combining process monitoring using online, PAT-compatible analyzers with solid process engineering principles and advanced process modeling techniques, we enable processes to be actively controlled to compensate for minor input variations (such as raw materials), so that the specifications for the final product will be closer to the ideal target.

Combine granulation with drying in one machine for a smaller footprint and less capital expense.

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Capacities UltimaPro Size 10 25 75 150 300 400 600 900 1200 Standard Capacity Range Litres 3.0-7.0 7.5-17.5 22.5-52.5 45-105 90-210 120-280 180-420 210-630 360-840 Typical Batch Weight kg 3 11 30 60 120 160 240 350 480

For more information GEA Pharma & Healthcare pharma@gea.com gea.com/contact

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GEA Pharma & Healthcare GEA Process Engineering nv

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